A 'fluid' or 'liquid' design is some kind of 'holy grail' of web design. This site is an example of such a fluid design: the entire browser-screen is used for the website. Fluid design often has a drawback: on high screen resolutions, the lines tend to get very long. That reduces the readability.
Multi-column solutions with new problems
Printed media, such as newspapers and magazines, solve this problem by using multiple (text) columns on a page. Unfortunately, there is no real multicolumn-support in current web standards. Therefor most sites use a fixed (narrow) width, and/or 'simulate' columns in HTML. Both solutions are not dynamic: on higher resolutions there's still quite a loss of 'screen real estate'.
The upcoming CSS3 standard provides webdevelopers with Multi-column support ↑. But the standard isn't even final yet. Worse, Microsoft tends to be very, very slow at adopting the standards in their Internet Explorer webbrowser, if ever.; IE7 doesn't even support the current CSS2.1 standards properly, let alone CSS3.



